AstraZeneca PLC, a leading global biopharmaceutical company, announced today that it has received a grant from the FDA to pursue new research on the anti-cholesterol drug rosuvastatin. Crestor, a cholesterol drug that belongs to the class of cholesterol-lowering drugs, has shown significant clinical benefit for patients with cardiovascular diseases. Currently available in the US, rosuvastatin is approved for the treatment of patients with primary hyperlipidemia and other lipid-related diseases, including coronary heart disease, diabetes, and hypertension.
The grant provides a total of $3 million from the US FDA for the specific research program, which is expected to generate a total of $2.2 million in additional annual revenue. The US FDA has approved rosuvastatin as the first oral anti-cholesterol drug to treat patients with lipid-related diseases.
“The potential benefits of rosuvastatin are enormous,” said Dr. John Jenkins, Chief Science Officer of AstraZeneca PLC. “This grant provides a significant amount of additional funding for a number of innovative clinical studies that have identified novel therapeutic targets for lipid-related diseases.”
“The results of the Phase 3 clinical study are promising,” said Dr. Daniel Johnson, Chief Scientific Officer of AstraZeneca PLC. “They provide new insights into the mechanism of lipid-related diseases and will allow the development of new treatments for these diseases.”
The findings of the study will help further our understanding of the role of rosuvastatin in the treatment of patients with hyperlipidemia and other lipid-related diseases. The trial is expected to run by the end of the year, allowing the development of more efficient therapeutic methods for patients with these diseases.
The study was conducted by Dr. Jenkins at the University of Cincinnati; Dr. Johnson at the University of Pennsylvania; and Dr. Johnson and Dr. Johnson at the University of Pennsylvania. The study will involve a combination of rosuvastatin (Zyvox) and the lipid-lowering agent, diethylstilboestrol (DES). DES is a non-steroidal anti-inflammatory drug (NSAID), which is known to be a useful adjunct to lipid lowering. Rosuvastatin was evaluated in a randomized, double-blind, placebo-controlled, parallel-group study in more than 3,300 patients with hyperlipidemia. The study was conducted at the University of Cincinnati and was funded by AstraZeneca PLC.
Rosuvastatin is indicated for the treatment of hyperlipidemia in patients with heart failure, coronary heart disease, and other lipid-related diseases, including coronary heart disease. The study included patients aged 40 to 70 years and had a serum lipid level of at least 2.0 mmol/L. Patients had been treated with rosuvastatin for at least 4 weeks. Rosuvastatin was well tolerated in the study. In addition, rosuvastatin was well tolerated in the study.
“This grant provides an important milestone in the development of rosuvastatin as an anti-cholesterol drug,” said Dr.
The study is designed to evaluate the effects of rosuvastatin on patients with lipid-related diseases.
The trial is also being conducted to evaluate the impact of rosuvastatin on patients with hyperlipidemia and other lipid-related diseases. In addition, patients who take rosuvastatin will be monitored for signs of worsening lipid levels, including a worsening of hypercholesterolemia, liver function abnormalities, and an increase in the risk of cardiovascular events. The trial will also evaluate the impact of rosuvastatin on the safety of the lipid-lowering agent, DES.
“Our hope is that this grant will lead to more robust research on the anti-cholesterol drug rosuvastatin in patients with hypercholesterolemia,” said Dr. Mark M. Davis, Chief Scientific Officer of AstraZeneca PLC.
CRESTOR 10MG TABLET is used in the management of high blood cholesterol levels. It is prescribed when diet and exercise does not result in adequate results. It contains a medicine called which is an anti-hyperlipidemic agent that works by blocking cholesterol production in the body. It also makes your body eliminate lipids particles from the blood.
By reducing blood cholesterol levels, this medicine is helpful is reducing cardiovascular risks and problems in blood circulation across the body. While taking CRESTOR 10MG TABLET, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results.
Before taking CRESTOR 10MG TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diabetes, thyroid problems, or a family history of muscle disorders. Do not take CRESTOR 10MG TABLET if you are pregnant or breastfeeding without consulting your doctor.
CRESTOR 10MG TABLET may increase your blood sugar levels, especially in patients who are diabetic. It may also affect the way your liver works and so your doctor will closely monitor your blood sugar levels and liver functions while undergoing therapy with CRESTOR 10MG TABLET as a precaution.
The most common side effects of taking CRESTOR 10MG TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache. Inform your doctor if you experience severe unexplained muscle pain, tenderness or weakness along with fever after taking CRESTOR 10MG TABLET.
How should I take CRESTOR 10MG TABLET? The dosage of CRESTOR 10MG TABLET depends on the patient’s age, BMI, main cardiac function, as well as other factors. Before beginning the course of CRESTOR 10MG TABLET, inform your doctor about your history and any ongoing medications you are taking.For adults, the initial dose is 5mg once daily before rising to 10mg once daily. For patients with kidney problems, the dose is 2.5mg to 10mg per day to improve your risk of severe kidney side effects. The dose may be raised to be taken two more times a day while you are using CRESTOR 10MG TABLET to avoid further kidney side effects.
For children, the initial dose is 2.5mg daily taken orally, three times daily, as required, over 4 weeks. The dose may be increased to 5mg or decreased to a lower dose of 2.5mg per day to avoid kidney side effects, if using the drug in children. The dosage may be further increased to 10mg once daily as well, once you receive treatment.
The doctor will ensure that the patient is safe for sex, given that CRESTOR 10MG TABLET is FDA-approved for the treatment of adult hyperlipidemia. You should also inform the doctor if you have any condition that affects muscle mass, liver function or heart rate. If you are prescribed CRESTOR 10MG TABLET, you must consult the doctor about any pending treatment and will be required to sign a conditions for treatment contract for CRESTOR 10MG TABLET.
How is CRESTOR 10MG TABLET prescribed? Both oral and injection CRESTOR 10MG TABLET are given as a single injection. It is effective in reducing the blood cholesterol levels while providing relief for all blood glucose levels while providing similar results as fighting lipid disorders as treating cholesterol levels levels.The starting dose of CRESTOR 10MG TABLET is 5 mg, taken orally, once a day. You should follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor. The recommended dose for adults is 20 mg once a day, which should be taken at the same time each day.
The doctor will need to be consulted if you are prescribed lower doses of CRESTOR 10MG TABLET as a precaution. Do not take multiple doses at once without consulting your doctor.
Inform your doctor if you have any skin problems or liver problems. You must also inform your doctor if you are breastfeeding without seeing your doctor.
For adults with high cholesterol, it is recommended that you should take 5mg of CRESTOR 10MG TABLET once daily for at least 4 hours, followed by a decrease to 0.5mg of oral capsules once daily after 4 hours.
For patients with cholesterol dependent liver disease you will need to take 10mg of CRESTOR 10MG TABLET once daily, after a low-fat diet.
Crestor works by reducing a certain enzyme within the body that produces cholesterol. It belongs to a class of medications called statins.
Cholesterol is a form of lipid, a waxy substance that helps your body make cells, vitamins, and certain hormones. It is not inherently bad. Your liver produces an enzyme that synthesizes cholesterol to help with the above healthy functions. Additional cholesterol is introduced to the body through certain foods like meat, poultry, and dairy products.
There are two types of cholesterol: high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs). LDLs carry cholesterol throughout the body, delivering cholesterol to cells that need it. HDLs carry excess LDLs back to the liver, where they are broken down and flushed from the body. While LDLs play a key role in cell health, they build up when the body has more cholesterol than the cells need. This buildup turns into plaque in the arteries (blood vessels). As plaque covers the artery walls, the blood vessels become narrow. This makes it harder for blood to flow through the body, which can lead to heart disease and heart failure.
Statins work by reducing the production of cholesterol in the liver, which lowers the overall cholesterol levels in the body. Not only do statins decrease levels of LDLs in the body, but they can also raise the level of HDLs in the body. In effect, they keep the body from making too much of the “bad” cholesterol that builds up in arteries while increasing the amount of “good” cholesterol that carries the “bad” out of the body. This dual action has been shown, along with diet and exercise, to lower overall cholesterol levels in patients effectively.
Crestor Pill InstructionsThe dosage you need is determined by your kidney function, liver, and other factors. For example, if you have high-sensitivity/irregular cyclical muscular fatigue, it’s important to take a statin at least 60 minutes before you plan to have any activity. You can take it with or without food. You can take it with or without a meal. You can take it with or without a glass of water. Your doctor will tell you how many pills to take. It's important to take it at least 60 minutes before you plan to have any activity. You can take it at least 30 minutes before you plan to have any activity. You can take it at least 60 minutes before you plan to have any activity.